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Article

Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation.

Development (Cambridge, England) - 1 Jun 2007

Guo Qiuxia, Li James Y H

Abstract excerpt

The vertebrate Fgf8 gene produces multiple protein isoforms by alternative splicing. Two evolutionarily conserved spliceforms, Fgf8a and Fgf8b, exhibit distinct bioactivities, with Fgf8b having a more potent inductive activity due to higher affinity for Fgf receptors. To investigate the in vivo requirement for Fgf8b, we created a splice-site mutation abolishing Fgf8b expression in mice. Analysis of this mutant...

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Identifiers

PMID: 17507393
DOI: 10.1242/dev.004929
PMCID: PMC2518685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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