Article
Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Wilm B, Dahl E, Peters H, Balling R, Imai K
Abstract excerpt
The murine paired box-containing gene Pax1 is required for normal development of the vertebral column, the sternum, and the scapula. Previous studies have shown that three natural Pax1 mouse mutants, the undulated alleles, exhibit phenotypes of different severity in these skeletal elements. Nevertheless, these analyses have not clarified whether the semidominant Undulated short-tail (Uns) mutation, in which the...
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