Article
Kekkon5 is an extracellular regulator of BMP signaling.
Developmental biology - 1 Feb 2009
Evans Timothy A, Haridas Harita, Duffy Joseph B
Abstract excerpt
Precise spatial and temporal control of Drosophila Bone Morphogenetic Protein (BMP) signaling is achieved by a host of extracellular factors that modulate ligand distribution and activity. Here we describe Kekkon5 (Kek5), a transmembrane protein containing leucine-rich repeats (LRRs), as a novel regulator of BMP signaling in Drosophila. We find that loss or gain of kek5 disrupts crossvein development and alters...
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