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Article

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain.

Cell death and differentiation - 1 Oct 2003

Young C, Klocke B J, Tenkova T, Choi J, Labruyere J, Qin Y-Q, Holtzman D M, Roth K A, Olney J W

Abstract excerpt

A single episode of ethanol intoxication triggers widespread apoptotic neurodegeneration in the infant rat or mouse brain. The cell death process occurs over a 6-16 h period following ethanol administration, is accompanied by a robust display of caspase-3 enzyme activation, and meets ultrastructural criteria for apoptosis. Two apoptotic pathways (intrinsic and extrinsic) have been described, either of which may...

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Source

Identifiers

PMID: 14502238
DOI: 10.1038/sj.cdd.4401277

Genes

BAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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