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A single binge ethanol exposure is apoptotic within hours across neurodevelopment and partially regulated by the <i>Myt1l</i> gene

2025-06-29

Abstract excerpt

Ethanol rapidly produces widespread neuronal apoptosis during early development, but this susceptibility declines as the brain matures. In previous research, we found Myt1l (a proneuronal transcription factor) mutations can cause precocious differentiation, neuronal immaturity, and transcriptomic alterations, including many in apoptotic regulators. Therefore, we used a recently developed Myt1l haploinsufficient...

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Literature Corpus work
3717e4d7-73b8-50b5-9004-509fa1f1ac76
DOI
10.1101/2025.06.27.662020
Open publication

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A single binge ethanol exposure is apoptotic within hours across neurodevelopment and partially regulated by the <i>Myt1l</i> geneDOI 10.1101/2025.06.27.662020
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