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Article

Programmed cell death is impaired in the developing brain of FMR1 mutants.

Developmental neuroscience - 1 Jan 2013

Cheng Ying, Corbin Joshua G, Levy Richard J

Abstract excerpt

Fragile X syndrome (FXS), due to transcriptional silencing of fragile X mental retardation protein (FMRP), is characterized by excess synaptic connections and impaired dendrite maturation. Programmed cell death (PCD) is critical for synaptogenesis and elimination of aberrant neuronal connections in the developing brain; however, the role of FMRP in PCD is unknown. The aim of this work was to assess the intrinsic...

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Identifiers

PMID: 23900139
DOI: 10.1159/000353248
PMCID: PMC5116766

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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