Article
Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex.
Anesthesia and analgesia - 1 Apr 2013
Istaphanous George K, Ward Christopher G, Nan Xinyu, Hughes Elizabeth A, McCann John C, McAuliffe John J, Danzer Steve C, Loepke Andreas W
Abstract excerpt
BACKGROUND: Accumulating evidence indicates that isoflurane and other, similarly acting anesthetics exert neurotoxic effects in neonatal animals. However, neither the identity of dying cortical cells nor the extent of cortical cell loss has been sufficiently characterized. We conducted the present study to immunohistochemically identify the dying cells and to quantify the fraction of cells undergoing apoptotic...
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