Article
Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Nov 2004
Houde Caroline, Banks Kathleen G, Coulombe Nathalie, Rasper Dita, Grimm Erich, Roy Sophie, Simpson Elizabeth M, Nicholson Donald W
Abstract excerpt
Caspase-3-deficient mice of the 129S1/SvImJ (129) strain show severe brain development defects resulting in brain overgrowth and perinatal lethality, whereas on the C57BL/6J (B6) background, these mice develop normally. We therefore sought to identify the strain-dependent ameliorating gene. We biochemically isolated caspase-7 from B6-caspase-3-null (Casp3-/-) tissues as being the enzyme with caspase-3-like...
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