Article
Structure-function relationships of the initiation complex of HIV-1 reverse transcription: the case of mutant viruses using tRNA(His) as primer.
Nucleic acids research - 1 Oct 2003
Rigourd Mickaël, Goldschmidt Valérie, Brulé Fabienne, Morrow Casey D, Ehresmann Bernard, Ehresmann Chantal, Marquet Roland
Abstract excerpt
Reverse transcription of HIV-1 RNA is initiated from the 3' end of a tRNA3Lys molecule annealed to the primer binding site (PBS). An additional interaction between the anticodon loop of tRNA3Lys and a viral A-rich loop is required for efficient initiation of reverse transcription of the HIV-1 MAL isolate. In the HIV-1 HXB2 isolate, simultaneous mutations of the PBS and the A-rich loop (mutant His-AC), but not of...
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