Article
HIV type 1 that select tRNA(His) or tRNA(Lys1,2) as primers for reverse transcription exhibit different infectivities in peripheral blood mononuclear cells.
AIDS research and human retroviruses - 1 Apr 2004
Moore Kenda L, Kosloff Barry R, Kelly Nathan J, Kirkman Richard L, Dupuy Lesley C, McPherson Sylvia, Morrow Casey D
Abstract excerpt
The replication in human peripheral blood mononuclear cells (PBMC) of unique HIV-1 that select tRNA(His) or tRNA(Lys1,2) for reverse transcription was compared to the wild-type virus that uses tRNA(Lys,3). HIV-1 with only the primer-binding site (PBS) changed to be complementary to these alternative tRNAs initially replicated more slowly than the wild-type virus in PBMC, although all viruses eventually reached...
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