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Article

Initiation of HIV-2 reverse transcription: a secondary structure model of the RNA-tRNA(Lys3) duplex.

Nucleic acids research - 1 Jul 2001

Freund F, Boulmé F, Litvak S, Tarrago-Litvak L

Abstract excerpt

Human immunodeficiency virus type 2 (HIV-2) reverse transcription is initiated from cellular tRNA(Lys3) partially annealed to the RNA viral genome at the primer binding site (PBS). This annealing involves interactions between two highly structured RNA molecules. In contrast to HIV-1, in which the reverse transcription initiation complex has been thoroughly studied, there is still little information regarding a...

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Identifiers

PMID: 11433020
DOI: 10.1093/nar/29.13.2757
PMCID: PMC55777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Initiation of HIV-2 reverse transcription: a secondary structure model of the RNA-tRNA(Lys3) duplex.PMID 11433020Read ↗

Mutational analysis of the tRNA3Lys/HIV-1 RNA (primer/template) complex.Semantic proximity Read ↗

Does the HIV-1 primer activation signal interact with tRNA3(Lys) during the initiation of reverse transcription?Semantic proximity Read ↗

On the importance of the primer activation signal for initiation of tRNA(lys3)-primed reverse transcription of the HIV-1 RNA genome.Semantic proximity Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

Initiation of HIV-1 Reverse Transcription Is Regulated by a Primer Activation SignalSemantic proximity Read ↗

Switching the in vitro tRNA usage of HIV-1 by simultaneous adaptation of the PBS and PAS.Semantic proximity Read ↗

HIV-1 nucleocapsid protein and the secondary structure of the binary complex formed between tRNA(Lys.3) and viral RNA template play different roles during initiation of (-) strand DNA reverse transcription.Semantic proximity Read ↗

Efficient initiation of HIV-1 reverse transcription in vitro. Requirement for RNA sequences downstream of the primer binding site abrogated by nucleocapsid protein-dependent primer-template interactions.Semantic proximity Read ↗

Efficient extension of a misaligned tRNA-primer during replication of the HIV-1 retrovirus.Semantic proximity Read ↗

A structured RNA motif is involved in correct placement of the tRNA(3)(Lys) primer onto the human immunodeficiency virus genome.Semantic proximity Read ↗

Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription.Semantic proximity Read ↗

Extended Interactions between HIV-1 Viral RNA and tRNALys3 Are Important to Maintain Viral RNA Integrity.Semantic proximity Read ↗

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