Article
Mutational analysis of the tRNA3Lys/HIV-1 RNA (primer/template) complex.
Nucleic acids research - 1 Mar 1998
Isel C, Keith G, Ehresmann B, Ehresmann C, Marquet R
Abstract excerpt
Retroviruses use a specific tRNA, whose 3' end is complementary to the 18 nucleotides of the primer binding site (PBS), to prime reverse transcription. Previous work has shown that initiation of HIV-1 reverse transcription is a specific process, in contrast with the subsequent elongation phase. H...
Topics
- Anticodon
- Base Sequence
- DNA Primers
- HIV-1
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Transfer, Lys
- RNA, Viral