Article
Genetic analysis of the U5-PBS of a novel HIV-1 reveals multiple interactions between the tRNA and RNA genome required for initiation of reverse transcription.
RNA (New York, N.Y.) - 1 Apr 1998
Zhang Z, Kang S M, Li Y, Morrow C D
Abstract excerpt
A novel HIV-1 genome that stably utilizes tRNA(His) rather than tRNA(Lys,3) to initiate reverse transcription was used to study features for the interaction between the tRNA and viral RNA genome. In addition to a primer binding site (PBS) complementary to tRNA(His), this virus contains a six-nucl...
Topics
- Anticodon
- Base Sequence
- Binding Sites
- Genome, Viral
- Genotype
- HIV-1
- Molecular Sequence Data
- Mutagenesis
- Nucleic Acid Conformation
- Polymerase Chain Reaction
- Proviruses
- RNA, Transfer, His
- RNA, Viral
- Sequence Analysis, DNA
- Transcription, Genetic
- Transfection
- Viral Proteins
- Virus Integration