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Article

Switching the in vitro tRNA usage of HIV-1 by simultaneous adaptation of the PBS and PAS.

RNA (New York, N.Y.) - 1 Mar 2002

Beerens Nancy, Berkhout Ben

Abstract excerpt

Reverse transcription of the HIV-1 RNA genome is primed by the cellular tRNA(lys3) molecule that anneals to a complementary sequence in the viral genome, the primer-binding site (PBS). Additional interactions between the tRNA primer and the viral RNA were proposed to play a role in reverse transcription. We recently identified an 8-nt element in the U5 region upstream of the PBS that is critical for initiation...

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Identifiers

PMID: 12003495
DOI: 10.1017/s1355838202028194
PMCID: PMC1370257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Switching the in vitro tRNA usage of HIV-1 by simultaneous adaptation of the PBS and PAS.PMID 12003495Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

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Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.Semantic proximity Read ↗

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