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Article

Does the HIV-1 primer activation signal interact with tRNA3(Lys) during the initiation of reverse transcription?

Nucleic acids research - 1 Feb 2003

Goldschmidt Valérie, Ehresmann Chantal, Ehresmann Bernard, Marquet Roland

Abstract excerpt

Reverse transcription of HIV-1 RNA is primed by a tRNA3(Lys) molecule bound at the primer binding site (PBS). Complex intermolecular interactions were proposed between tRNA3(Lys) and the RNA of the HIV-1 Mal isolate. Recently, an alternative interaction was proposed between the TPsiC stem of tRNA3(Lys) and a primer activation signal (PAS) of the Lai and Hxb2 RNAs, suggesting major structural variations in the...

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Share to DNA, Viral
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HIV Reverse Transcriptase

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Source

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Identifiers

PMID: 12560480
DOI: 10.1093/nar/gkg187
PMCID: PMC149207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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