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Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanization

2021-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed a live attenuated Leishmania major centrin gene deleted parasite strain ( LmCen -/- ) that induced protection against a homologous and heterologous challenges. The protection is mediated by IFNγ secreting CD4 + T effector cells and mult...

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Literature Corpus work
a62bda80-79ff-5457-bce6-43be75cfa47a
DOI
10.1101/2021.12.17.472620
Open publication

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Skin resident memory cells generated by the <i>L. major</i> centrin gene deleted parasites mediate protective immune response analogous to leishmanizationDOI 10.1101/2021.12.17.472620
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