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Article

Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2003

Simpson Pedro B, Mistry Monica S, Maki Richard A, Yang Weidong, Schwarz David A, Johnson Eric B, Lio Francisco M, Alleva David G

Abstract excerpt

APCs of the nonobese diabetic (NOD) mouse have a genetically programmed capacity to overexpress IL-12p40, a cytokine critical for development of pathogenic autoreactive Th1 cells. To determine whether a diabetes-associated NOD chromosomal locus (i.e., Idd) was responsible for this defect, LPS-stimulated macrophages from several recombinant congenic inbred mice with Idd loci on a C57BL/6 background or with...

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Identifiers

PMID: 14500624
DOI: 10.4049/jimmunol.171.7.3333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cuttine edge: diabetes-associated quantitative trait locus, Idd4, is responsible for the IL-12p40 overexpression defect in nonobese diabetic (NOD) mice.PMID 14500624Read ↗

Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

Congenic mice reveal genetic epistasis and overlapping disease loci for autoimmune diabetes and listeriosis.Semantic proximity Read ↗

NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation.Semantic proximity Read ↗

A susceptibility allele from a non-diabetes-prone mouse strain accelerates diabetes in NOD congenic mice.Semantic proximity Read ↗

Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation.Semantic proximity Read ↗

Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: identification of two potential candidate subloci.Semantic proximity Read ↗

Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.Semantic proximity Read ↗

Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.Semantic proximity Read ↗

Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.Semantic proximity Read ↗

Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse.Semantic proximity Read ↗

Gene-gene interactions in the NOD mouse model of type 1 diabetes.Semantic proximity Read ↗

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