Article
E-cadherin germline missense mutations and cell phenotype: evidence for the independence of cell invasion on the motile capabilities of the cells.
Human molecular genetics - 15 Nov 2003
Suriano Gianpaolo, Oliveira Maria José, Huntsman David, Mateus Ana Rita, Ferreira Paulo, Casares Fernando, Oliveira Carla, Carneiro Fátima, Machado Josée Carlos, Mareel Marc, Seruca Raquel
Abstract excerpt
In Hereditary Diffuse Gastric Cancer syndrome, E-cadherin germline mutations of the missense type harbour significant functional consequences. In this study, we have characterised the effect of T340A, A617T, A634V and V832M E-cadherin germline missense mutations on cell morphology, motility and proliferation. Wild-type E-cadherin and A617T expressing cells have an epithelial-like morphology, with polarised cells...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, CD
- Blotting, Western
- CHO Cells
- Cadherins
- Cell Division
- Cell Movement
- Cell Polarity
- Codon, Nonsense
- Collagen Type I
- Cricetinae
- Cricetulus