Article
Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.
Human molecular genetics - 1 Oct 2009
Deplazes Joëlle, Fuchs Margit, Rauser Sandra, Genth Harald, Lengyel Ernst, Busch Raymonde, Luber Birgit
Abstract excerpt
Recent evidence suggests a close association between extracellular E-cadherin mutation in diffuse-type gastric carcinoma and the acquisition of a migratory phenotype of tumour cells. To characterize the cellular machinery that mediates the gain of motility of tumour cells with mutant E-cadherin, we turned to the small Rho GTPases Rac1 and Rho because they have been implicated in pathological processes including...
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