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Article

E-cadherin mutations and cell motility: a genotype-phenotype correlation.

Experimental cell research - 1 May 2009

Mateus Ana Rita, Simões-Correia Joana, Figueiredo Joana, Heindl Stefan, Alves Catarina Castro, Suriano Gianpaolo, Luber Birgit, Seruca Raquel

Abstract excerpt

E-cadherin has a determinant role in tumour progression, acting as an invasion and metastasis suppressor. Germline mutations of E-cadherin gene (CDH1) occur in 30% of families with Hereditary Diffuse Gastric Cancer (HDGC); of these 23% are missense mutations. The CDH1 missense mutations described to date span the entire gene and some lead to significant functional consequences. In this study, we explored the...

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Source

Identifiers

PMID: 19268661
DOI: 10.1016/j.yexcr.2009.02.020

Genes

CDH1
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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