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Article

Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus.

Infection and immunity - 1 Oct 2003

Cheng Shaoji, Nguyen M Hong, Zhang Zongde, Jia Hongyan, Handfield Martin, Clancy Cornelius J

Abstract excerpt

Reintroducing URA3 to its native locus in Candida albicans not5, not3, bur2, and kel1 disruption mutants enabled us to directly compare strains with control strain CAI-12. We showed that URA3 position affected orotidine 5'-monophosphate decarboxylase activity, hyphal morphogenesis, adherence, and mortality in murine disseminated candidiasis. After URA3 was reintroduced to its native locus, only NOT5 could be...

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Identifiers

PMID: 14500538
DOI: 10.1128/IAI.71.10.6101-6103.2003
PMCID: PMC201070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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