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Article

Deletion of the NOT4 gene impairs hyphal development and pathogenicity in Candida albicans.

Microbiology (Reading, England) - 1 Jan 2004

Krueger Karl E, Ghosh Anup K, Krom Bastiaan P, Cihlar Ronald L

Abstract excerpt

The Candida albicans NOT4 gene was disrupted in order to investigate the role of Not4p in growth, morphogenesis and pathogenicity. Heterozygote (NOT4/not4), null (not4/not4) and reconstructed heterozygote ([NOT4]/not4) strains of C. albicans, as well as CAF2-1, the parental strain, were grown under conditions that promote hyphal formation. When cultured in liquid medium 199 the heterozygote, reconstructed and...

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Identifiers

PMID: 14702416
DOI: 10.1099/mic.0.26792-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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