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Article

Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1.

Molecular microbiology - 1 Nov 2003

Limjindaporn Thawornchai, Khalaf Roy A, Fonzi William A

Abstract excerpt

Nitrogen acquisition and metabolism is central to microbial growth. A conserved family of zinc-finger containing transcriptional regulators known as GATA-factors ensures efficient utilization of available nitrogen sources by fungi. GATA factors activate expression of nitrogen catabolic pathways when preferred nitrogen sources are absent or limiting, a phenomenon known as nitrogen catabolite repression. GAT1 of...

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PMID: 14617156
DOI: 10.1046/j.1365-2958.2003.03747.x

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