Article
The role of Candida albicans NOT5 in virulence depends upon diverse host factors in vivo.
Infection and immunity - 1 Nov 2005
Cheng Shaoji, Clancy Cornelius J, Checkley Mary Ann, Zhang Zongde, Wozniak Karen L, Seshan Kalpathi R, Jia Hong Yan, Fidel Paul, Cole Garry, Nguyen M Hong
Abstract excerpt
We previously identified Candida albicans Not5p as an immunogenic protein expressed during oropharyngeal candidiasis (OPC). In this study, we demonstrate that C. albicans NOT5 reverses the growth defects of a Saccharomyces cerevisiae not5 mutant strain at 37 degrees C, suggesting that the genes share at least some functional equivalence. We implicate C. albicans NOT5 in the pathogenesis of disseminated...
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