Strains and Strategies for Large-Scale Gene Deletion Studies of the Diploid Human Fungal Pathogen <i>Candida albicans</i>

Abstract excerpt

Candida albicans is the most common human fungal pathogen and causes significant morbidity and mortality worldwide. Nevertheless, the basic principles of C. albicans pathogenesis remain poorly understood. Of central importance to the study of this organism is the ability to generate homozygous knockout mutants and to analyze them in a mammalian model of pathogenesis. C. albicans is diploid, and current strategies...

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