Isogenic strain construction and gene mapping in Candida albicans.

doi:10.1093/genetics/134.3.717

Back to search

Article

Isogenic strain construction and gene mapping in Candida albicans.

Genetics - 1 Jul 1993

Fonzi W A, Irwin M Y

Abstract excerpt

Genetic manipulation of Candida albicans is constrained by its diploid genome and asexual life cycle. Recessive mutations are not expressed when heterozygous and undesired mutations introduced in the course of random mutagenesis cannot be removed by genetic back-crossing. To circumvent these prob...

Topics

Base Sequence
Candida albicans
DNA, Single-Stranded
Genes, Fungal
Genes, Recessive
Genotype
Heterozygote
Homozygote
Molecular Sequence Data
Mutagenesis, Site-Directed
Restriction Mapping
Sequence Deletion

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.