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Article

Isogenic strain construction and gene mapping in Candida albicans.

Genetics - 1 Jul 1993

Fonzi W A, Irwin M Y

Abstract excerpt

Genetic manipulation of Candida albicans is constrained by its diploid genome and asexual life cycle. Recessive mutations are not expressed when heterozygous and undesired mutations introduced in the course of random mutagenesis cannot be removed by genetic back-crossing. To circumvent these problems, we developed a genotypic screen that permitted identification of a heterozygous recessive mutation at the URA3...

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Identifiers

PMID: 8349105
DOI: 10.1093/genetics/134.3.717
PMCID: PMC1205510

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Source receipt: pubmed, retrieved 7 Sept 2026.

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