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Article

The intracellular transport of chylomicrons requires the small GTPase, Sar1b.

Current opinion in lipidology - 1 Apr 2004

Shoulders Carol C, Stephens David J, Jones Bethan

Abstract excerpt

PURPOSE OF REVIEW: The transport of lipoproteins through the secretory pathways of enterocytes and hepatocytes is pivotal for whole-body lipid homeostasis. This review focuses on the assembly and structural evolution of COPII (coat protein) transport carriers that are essential for the transport of chylomicrons from the endoplasmic reticulum to the Golgi apparatus. RECENT FINDINGS: The assembly of endoplasmic...

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Source

Identifiers

PMID: 15017362
DOI: 10.1097/00041433-200404000-00012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The intracellular transport of chylomicrons requires the small GTPase, Sar1b.PMID 15017362Read ↗

Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders.Semantic proximity Read ↗

SAR1 paralogs differ biochemically in assembly of the COPII coatSemantic proximity Read ↗

Cargo selection in endoplasmic reticulum–to–Golgi transport and relevant diseasesSemantic proximity Read ↗

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.Semantic proximity Read ↗

Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivoSemantic proximity Read ↗

Assembly, organization, and function of the COPII coatSemantic proximity Read ↗

Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease.Semantic proximity Read ↗

Defining the cellular and molecular basis of Spondyloepiphyseal dysplasia tardaSemantic proximity Read ↗

Functional overlap between the mammalian <i>Sar1a</i> and <i>Sar1b</i> paralogs in vivoSemantic proximity Read ↗

Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle.Semantic proximity Read ↗

Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease.Semantic proximity Read ↗

The COPI coatomer regulates several steps of HDL metabolismSemantic proximity Read ↗

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