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Article

Comparison of the mutations induced by p-benzoquinone, a benzene metabolite, in human and mouse cells.

Mutation research - 31 Oct 2000

Nakayama A, Koyoshi S, Morisawa S, Yagi T

Abstract excerpt

Benzene is one of the chemicals widely contaminating the environment. Benzene is suggested to be a human leukemogen. When benzene is absorbed in the human body, it is metabolized firstly in the liver and subsequently in the bone marrow where it provokes initiation of leukemia. In the present study, we analyzed mutations induced by p-benzoquinone (p-BQ), a benzene metabolite, in human cells using a shuttle vector...

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PMID: 11027969
DOI: 10.1016/s1383-5718(00)00099-1

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