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Article

Identification of a 6-cM minimal deletion at 11q23.1-23.2 and exclusion of PPP2R1B gene as a deletion target in cervical cancer.

Cancer research - 1 Dec 2000

Pulido H A, Fakruddin M J, Chatterjee A, Esplin E D, Beleño N, Martinez G, Posso H, Evans G A, Murty V V

Abstract excerpt

Previous functional and deletion mapping studies on cervical cancer (CC) have implicated one or more tumor suppressor genes (TSGs) on chromosome 11 at q13 and q22-24 regions. Of these, the 11q22-24 region exhibits frequent allelic deletions in a variety of solid tumor types, suggesting the presence of critical genes for tumor suppression in this region. However, the precise region of deletion on 11q is not...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell
Chromosome Mapping
Chromosomes, Human, Pair 11
Female
Gene Deletion
Genes, Tumor Suppressor
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Heterozygosity

Middle Aged

Mutation

Phosphoprotein Phosphatases

Polymorphism, Single-Stranded Conformational

Uterine Cervical Neoplasms

Source

Identifiers

PMID: 11118052

Provenance

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Identification of a 6-cM minimal deletion at 11q23.1-23.2 and exclusion of PPP2R1B gene as a deletion target in cervical cancer.PMID 11118052Read ↗

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