Article
Analysis of T-cell receptor variability in transplanted patients with acute graft-versus-host disease.
Blood - 1 Nov 1992
Dietrich P Y, Caignard A, Diu A, Genevee C, Pico J L, Henry-Amar M, Bosq J, Angevin E, Triebel F, Hercend T
Abstract excerpt
T lymphocytes play a pivotal role in graft-versus-host disease (GVHD) and largely contribute to the graft-versus-leukemia (GVL) effect. Most mature T lymphocytes specifically recognize antigens through the alpha/beta T-cell receptor (TCR). Each alpha/beta TCR chain includes a constant region and a variable region, the latter being encoded by V-J alpha or V-D-J beta rearranged gene segments. To better characterize...
Topics
- Acute Disease
- Adult
- Blotting, Southern
- Bone Marrow Transplantation
- Female
- Gene Rearrangement, T-Lymphocyte
- Genetic Variation
- Graft vs Host Disease
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive