T-cell receptor beta chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia.

doi:10.1006/bcmd.1997.0127

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Article

T-cell receptor beta chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia.

Blood cells, molecules & diseases - 1 Jan 1997

Manz C Y, Dietrich P Y, Schnuriger V, Nissen C, Wodnar-Filipowicz A

Abstract excerpt

Aplastic anemia (AA) is characterized by multilineage bone marrow failure of unknown etiology. In order to assess the role of immune-mediated mechanisms in hematopoietic suppression, we examined the diversity of T lymphocyte repertoire in terms of variable (V) gene segment usage of the T cell rec...

Topics

Adult
Aged
Anemia, Aplastic
Bone Marrow
Bone Marrow Cells
Child, Preschool
Clone Cells
Female
Gene Expression
Genetic Variation
Humans
Male
Polymerase Chain Reaction
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 9215756
DOI: 10.1006/bcmd.1997.0127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9215756-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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