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Article

T-cell receptor beta chain variability in bone marrow and peripheral blood in severe acquired aplastic anemia.

Blood cells, molecules & diseases - 1 Jan 1997

Manz C Y, Dietrich P Y, Schnuriger V, Nissen C, Wodnar-Filipowicz A

Abstract excerpt

Aplastic anemia (AA) is characterized by multilineage bone marrow failure of unknown etiology. In order to assess the role of immune-mediated mechanisms in hematopoietic suppression, we examined the diversity of T lymphocyte repertoire in terms of variable (V) gene segment usage of the T cell receptor (TCR) beta chain in bone marrow and peripheral blood of six patients with severe untreated AA. Expression of...

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Identifiers

PMID: 9215756
DOI: 10.1006/bcmd.1997.0127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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