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Article

Identification of clonotypic IgH VDJ sequences in multiple myeloma.

Methods in molecular medicine - 1 Jan 2005

Taylor Brian J, Kriangkum Jitra, Strachan Erin R, Wizniak Juanita, Pilarski Linda M

Abstract excerpt

In multiple myeloma (MM) the rearranged immunoglobulin heavy chain (IgH) variable, diversity, and joining (VDJ) DNA sequence of malignant plasma cells (PCs) serves as a marker for cells in the MM clone. This clonotypic sequence can be isolated from MM PCs by reverse transcriptase polymerase chain reaction (RT-PCR) with consensus primers that amplify the rearranged IgH repertoire. This chapter focuses on the key...

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Identifiers

PMID: 15968099
DOI: 10.1385/1-59259-916-8:121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of clonotypic IgH VDJ sequences in multiple myeloma.PMID 15968099Read ↗

A High Frequency of Circulating B Cells Share Clonotypic Ig Heavy-Chain VDJ Rearrangements With Autologous Bone Marrow Plasma Cells in Multiple Myeloma, as Measured by Single-Cell and In Situ Reverse Transcriptase-Polymerase Chain ReactionSemantic proximity Read ↗

Single-Cell RNA Sequencing for the Detection of Clonotypic V(D)J Rearrangements in Multiple MyelomaSemantic proximity Read ↗

Deep Sequencing Reveals Oligoclonality At The Immunoglobulin Locus In Multiple Myeloma PatientsSemantic proximity Read ↗

Quantitative polymerase chain reaction analysis with allele-specific oligonucleotide primers for individual IgH VDJ regions to evaluate tumor burden in myeloma patients.Semantic proximity Read ↗

Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma.Semantic proximity Read ↗

CD34+ Cells in the Blood of Patients With Multiple Myeloma Express CD19 and IgH mRNA and Have Patient-Specific IgH VDJ Gene RearrangementsSemantic proximity Read ↗

Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients.Semantic proximity Read ↗

Prognostic value of deep sequencing method for minimal residual disease detection in multiple myelomaSemantic proximity Read ↗

Analysis of clonotypic switch junctions reveals multiple myeloma originates from a single class switch event with ongoing mutation in the isotype-switched progeny.Semantic proximity Read ↗

The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell.Semantic proximity Read ↗

Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell.Semantic proximity Read ↗

Massive parallel IGHV gene sequencing reveals a germinal center pathway in origins of human multiple myeloma.Semantic proximity Read ↗

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