Article
Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione.
Biochemical pharmacology - 6 Oct 1992
Sapora O, Paone A, Maggi A, Jenner T J, O'Neill P
Abstract excerpt
Incubation of the 2-nitroimidazole-aziridine, RSU-1069 [1-(2-nitro-1-imidazolyl)-3-(1-aziridinyl)-2-propanol], and its monomethylaziridine analogue, RSU-1131 [1-(2-nitro-1-imidazolyl)-3-(1-(2-methylaziridinyl))-2-propanol], with V79-4 mammalian cells for 2 hr under aerobic or hypoxic conditions induces mutations as measured at the hypoxanthine phosphoribosyl transferase locus. The ability of these agents to...
Topics
- Animals
- Aziridines
- Buthionine Sulfoximine
- Cell Hypoxia
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- Dose-Response Relationship, Drug
- Glutathione
- Methionine Sulfoximine