Article
Thromboxane augmentation of alloreactive T cell function.
Transplantation - 1 Sept 1992
Ruiz P, Rey L, Spurney R, Coffman T, Viciana A
Abstract excerpt
Thromboxane (Tx) plays a vital role in the dysfunction and ultimate rejection of MHC-disparate renal allografts. In addition to its potent vasoconstrictory properties, in vivo studies have implied that Tx is capable of promoting immune cytotoxic T cell function within transplants. In this study, we have examined the in vitro effect of Tx inhibition on alloreactive immune cells using MHC-disparate mouse strain...
Topics
- Animals
- Antibody Formation
- Cell Division
- Interleukin-2
- Isoantibodies
- Lymphocyte Activation
- Mice
- Mice, Inbred Strains
- Phenotype
- Receptors, Thromboxane
- T-Lymphocyte Subsets
- T-Lymphocytes