Article
Effective depletion of alloreactive lymphocytes from peripheral blood mononuclear cell preparations.
Transplantation - 15 Jan 1999
Garderet L, Snell V, Przepiorka D, Schenk T, Lu J G, Marini F, Gluckman E, Andreeff M, Champlin R E
Abstract excerpt
BACKGROUND: T cells present in an allogeneic bone marrow transplant may produce graft-versus-host disease but also contribute to immune reconstitution and enhance engraftment. Our aim was to separate alloreactive from nonalloreactive T lymphocytes, by performing a mixed lymphocyte culture (MLC) stimulation of donor cells, followed by selective depletion of activated cells expressing the high-affinity interleukin...
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