Effective depletion of alloreactive lymphocytes from peripheral blood mononuclear cell preparations.

doi:10.1097/00007890-199901150-00021

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Article

Effective depletion of alloreactive lymphocytes from peripheral blood mononuclear cell preparations.

Transplantation - 15 Jan 1999

Garderet L, Snell V, Przepiorka D, Schenk T, Lu J G, Marini F, Gluckman E, Andreeff M, Champlin R E

Abstract excerpt

BACKGROUND: T cells present in an allogeneic bone marrow transplant may produce graft-versus-host disease but also contribute to immune reconstitution and enhance engraftment. Our aim was to separate alloreactive from nonalloreactive T lymphocytes, by performing a mixed lymphocyte culture (MLC) s...

Topics

Blood Component Removal
Coculture Techniques
Humans
Isoantigens
Lymphocyte Culture Test, Mixed
Monocytes
Phenotype
Receptors, Interleukin-2
T-Lymphocytes
T-Lymphocytes, Cytotoxic

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