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Article

Modulation of alloreactivity in transplant recipients by phenotypic manipulation of donor endothelium.

The Journal of thoracic and cardiovascular surgery - 1 May 1995

Quigley R L, Switzer S S, Victor T A, Goldschmidt R A, Salinger M H, Arentzen C E, Alexander J C, Anderson R W

Abstract excerpt

Phenotypic manipulation of allograft endothelium to reduce immunogenicity would have a significant impact on transplantation. In this study we have demonstrated that random seeding of a heart allograft with endothelium, of host origin, not only promotes long-term survival, but reduces the requirement for pharmacologic immunosuppression. We propose that this simple technology could easily be extrapolated to the...

Topics

Animals
Endothelium
Heart Transplantation
Immunosuppression Therapy
Lymphocyte Culture Test, Mixed
Myocardium
Phenotype
Random Allocation
Rats
Rats, Inbred BN
Rats, Inbred Lew

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tissue Survival

Transplantation, Heterotopic

Transplantation, Homologous

Source

Identifiers

PMID: 7739251
DOI: 10.1016/S0022-5223(95)70315-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7739251-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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