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Article

Acute lethal graft-versus-host reaction induced by major histocompatibility complex class II-reactive T helper cell clones.

The Journal of experimental medicine - 1 May 1990

Lehmann P V, Schumm G, Moon D, Hurtenbach U, Falcioni F, Muller S, Nagy Z A

Abstract excerpt

T cell clones isolated from class II MHC-disparate MLR combinations, and specific for I-Ak and I-Ek molecules, respectively, are shown to induce acute lethal graft-vs-host disease in unirradiated recipients. Cytolytic and noncytolytic clones are equally efficient in this respect. The lethal disease is dependent on recognition of the stimulatory class II molecules in the host. The clones home to lungs and liver,...

Topics

Alleles
Animals
Anti-Inflammatory Agents
Cells, Cultured
Clone Cells
DNA Replication
Genes, MHC Class II
Graft vs Host Reaction
H-2 Antigens
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Mice

Mice, Inbred Strains

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 2139696
DOI: 10.1084/jem.171.5.1485
PMCID: PMC2187885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2139696-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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