Sequence analysis of HLA-DR4B1 subtypes: additional first domain variability is detected by oligonucleotide hybridization and nucleotide sequencing.

doi:10.1016/0198-8859(90)90110-b

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Article

Sequence analysis of HLA-DR4B1 subtypes: additional first domain variability is detected by oligonucleotide hybridization and nucleotide sequencing.

Human immunology - 1 Feb 1990

Lanchbury J S, Hall M A, Welsh K I, Panayi G S

Abstract excerpt

The stimulating capacity of HLA-DR4 variants in mixed leukocyte culture correlates with variation in the polymorphic regions of the first domains of their DR beta 1 chains. Variability between amino acids 67 and 86 appears largely to determine HLA-DR4,Dw type. We have used a combination of a DR4B...

Topics

Alleles
Amino Acid Sequence
Base Sequence
DNA Probes
HLA-DR4 Antigen
Humans
Molecular Sequence Data
Nucleic Acid Hybridization
Polymerase Chain Reaction
Polymorphism, Genetic

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