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Article

Polymorphism of HLA-DRw52-associated DRB1 genes as defined by sequence-specific oligonucleotide probe hybridization and sequencing.

Tissue antigens - 1 Oct 1991

Petersdorf E W, Smith A G, Haase A M, Martin P J, Hansen J A

Abstract excerpt

We have used group-specific DNA amplification and sequence-specific oligonucleotide probe (SSOP) hybridization to study DRB1 sequence polymorphisms associated with DR3, DRw11(5), DRw12(5), DRw13(w6), DRw14(w6) and DRw8 alleles. Group-specific amplification of DRw52-associated DRB1 alleles was achieved using a 5' amplification primer designed to hybridize with a first hypervariable region (HVR) sequence common to...

Topics

Alleles
Amino Acid Sequence
Base Sequence
HLA-DR Antigens
HLA-DR Serological Subtypes
HLA-DRB1 Chains
Histocompatibility Antigens Class II
Humans
Molecular Sequence Data
Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Polymorphism, Genetic

Prospective Studies

Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 1801307
DOI: 10.1111/j.1399-0039.1991.tb01891.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1801307-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Polymorphism of HLA-DRw52-associated DRB1 genes as defined by sequence-specific oligonucleotide probe hybridization and sequencing.PMID 1801307Read ↗

HLA-DRw52-associated DRB1 alleles: identification using polymerase chain reaction-amplified DNA, sequence-specific oligonucleotide probes, and a chemiluminescent detection system.Semantic proximity Read ↗

Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRB1 first domain.Semantic proximity Read ↗

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HLA-DR typing using DNA amplification by the polymerase chain reaction and sequential hybridization to sequence-specific oligonucleotide probes.Semantic proximity Read ↗

Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113.Semantic proximity Read ↗

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Complete coding sequences and haplotypic associations of HLA-B*0707, -B*1524, -B*4405, -B*4802, -DRB1*0409, -DRB1*0411, -DRB1*1115, -DRB1*1305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and DRB4.Semantic proximity Read ↗

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