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Article

Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRB1 first domain.

Immunogenetics - 1 Jan 1991

Petersdorf E W, Smith A G, Mickelson E M, Martin P J, Hansen J A

Abstract excerpt

We have studied DRB1 sequence polymorphisms associated with DR4 subtypes using DR4-specific DNA amplification and sequence-specific oligonucleotide probe (SSOP) hybridization. The 5' amplification primer was designed to hybridize with a unique sequence in the first hypervariable region (HVR) of t...

Topics

Alleles
Base Sequence
Gene Amplification
Gene Frequency
Genotype
HLA-DR4 Antigen
Homozygote
Humans
Molecular Sequence Data
Nucleic Acid Hybridization
Oligonucleotide Probes
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 2026461
DOI: 10.1007/BF00230505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2026461-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRB1 first domain.PMID 2026461Read ↗

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Nucleotide sequence of a novel HLA-DRB4B1 allele, DRB1*0409.Semantic proximity Read ↗

Identification of a novel HLA-DRB1 allele (DRB1*1147)* by sequence-based typing in eight siblings.Semantic proximity Read ↗

HLA-DRB1 first domain sequences of two new DR11 alleles and one novel DR4 allele.Semantic proximity Read ↗

Identification of a novel DR4 allele, DRB1*0442.Semantic proximity Read ↗

Sequence analysis of HLA-DR4B1 subtypes: additional first domain variability is detected by oligonucleotide hybridization and nucleotide sequencing.Semantic proximity Read ↗

A real-time PCR approach for rapid high resolution subtyping of HLA-DRB1*04.Semantic proximity Read ↗

Identification of a new DRB4 allele (DRB4*0105) by sequence-based typing.Semantic proximity Read ↗

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