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Article

Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRB1 first domain.

Immunogenetics - 1 Jan 1991

Petersdorf E W, Smith A G, Mickelson E M, Martin P J, Hansen J A

Abstract excerpt

We have studied DRB1 sequence polymorphisms associated with DR4 subtypes using DR4-specific DNA amplification and sequence-specific oligonucleotide probe (SSOP) hybridization. The 5' amplification primer was designed to hybridize with a unique sequence in the first hypervariable region (HVR) of the DRB1 second exon of all known DR4 alleles; the 3' primer was designed to hybridize with an intron sequence common to...

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PMID: 2026461
DOI: 10.1007/BF00230505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRB1 first domain.PMID 2026461Read ↗

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Sequence analysis of HLA-DR4B1 subtypes: additional first domain variability is detected by oligonucleotide hybridization and nucleotide sequencing.Semantic proximity Read ↗

A real-time PCR approach for rapid high resolution subtyping of HLA-DRB1*04.Semantic proximity Read ↗

Identification of a new DRB4 allele (DRB4*0105) by sequence-based typing.Semantic proximity Read ↗

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