Omission of the deconjugation step in urine analysis and the unaltered outcome of CYP2D6 phenotyping with dextromethorphan.

doi:10.1007/BF03189819

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Article

Omission of the deconjugation step in urine analysis and the unaltered outcome of CYP2D6 phenotyping with dextromethorphan.

European journal of drug metabolism and pharmacokinetics - 1 Jan 2000

Basci N E, Bozkurt A, Kayaalp S O, Sayal A, Isimer A

Abstract excerpt

The present study was aimed at determining whether the deconjugation step in chemical analysis could be omitted without altering the outcome of phenotyping CYP2D6 with dextromethorphan. This drug and its metabolite, dextrorphan, were assayed by high-performance liquid chromatography (HPLC) in uri...

Topics

Adolescent
Adult
Antitussive Agents
Cytochrome P-450 CYP2D6
Dextromethorphan
Humans
Male
Phenotype

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