p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus.

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Article

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus.

Oncogene - 1 Oct 1992

Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen N M, Rabbitts P

Abstract excerpt

Bronchial epithelial dysplasia is believed to precede invasive squamous cell carcinoma of the lung. Six paired dysplasia and tumour samples were distinguished histologically in sections of formalin-fixed paraffin-embedded lung tissue from patients with lung cancer. Additionally, samples of dyspla...

Topics

Base Sequence
Bronchi
Chromosome Aberrations
Chromosomes, Human, Pair 3
Genes, p53
Genotype
Heterozygote
Humans
Lung Neoplasms
Molecular Sequence Data
Mutation
Phenotype
Precancerous Conditions

Source

Open in PubMed

Identifiers

PMID: 1408139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1408139-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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