Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus.

Oncogene - 1 Oct 1992

Sundaresan V, Ganly P, Hasleton P, Rudd R, Sinha G, Bleehen N M, Rabbitts P

Abstract excerpt

Bronchial epithelial dysplasia is believed to precede invasive squamous cell carcinoma of the lung. Six paired dysplasia and tumour samples were distinguished histologically in sections of formalin-fixed paraffin-embedded lung tissue from patients with lung cancer. Additionally, samples of dysplastic bronchial epithelium were obtained from patients without lung tumours. Microdissection of the unstained sections...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Genotype

Share to Heterozygote

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Source

Identifiers

PMID: 1408139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus.PMID 1408139Read ↗

Somatic genetic changes in lung cancer and precancerous lesions.Semantic proximity Read ↗

Sequential molecular genetic changes in lung cancer development.Semantic proximity Read ↗

Multiple high-grade bronchial dysplasia and squamous cell carcinoma: concordant and discordant mutations.Semantic proximity Read ↗

High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.Semantic proximity Read ↗

In-depth analysis of molecular alterations within normal and tumour tissue from an entire bronchial tree.Semantic proximity Read ↗

Allele-specific chromosome 3p deletions occur at an early stage in the pathogenesis of lung carcinoma.Semantic proximity Read ↗

Somatic genetic changes accompanying lung tumor development.Semantic proximity Read ↗

Evaluation of p53 gene mutation and loss of heterozygosity of 3p, 9p and 17p in precancerous lesions of 29 lung cancer patients.Semantic proximity Read ↗

Paraffin wax-embedded material as a source of DNA for the detection of somatic genetic changes.Semantic proximity Read ↗

3p21, 5q21, 9p21 and 17p13 allelic deletions accumulate in the dysplastic spectrum of laryngeal carcinogenesis and precede malignant transformation.Semantic proximity Read ↗

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.Semantic proximity Read ↗

p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with nonsmall cell lung carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.