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Article

Sequential molecular genetic changes in lung cancer development.

Oncogene - 21 Dec 1995

Chung G T, Sundaresan V, Hasleton P, Rudd R, Taylor R, Rabbitts P H

Abstract excerpt

Epithelial tumours develop through a sequence of pre-invasive lesions of increasing disarray driven by underlying somatic genetic changes. We have studied the occurrence of the two most common somatic genetic changes associated with lung cancer in a series of premalignant bronchial lesions representing different stages in lung tumorigenesis. We present evidence that allele loss on chromosome 3 precedes damage to...

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PMID: 8545116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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