Article
Sequential molecular genetic changes in lung cancer development.
Oncogene - 21 Dec 1995
Chung G T, Sundaresan V, Hasleton P, Rudd R, Taylor R, Rabbitts P H
Abstract excerpt
Epithelial tumours develop through a sequence of pre-invasive lesions of increasing disarray driven by underlying somatic genetic changes. We have studied the occurrence of the two most common somatic genetic changes associated with lung cancer in a series of premalignant bronchial lesions repres...
Topics
- Base Sequence
- Chromosome Deletion
- Chromosomes, Human, Pair 3
- Genes, p53
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation