Analysis of temperature-sensitive functions of Fos: lack of a correlation between transformation and TRE-dependent trans-activation.

Article

Analysis of temperature-sensitive functions of Fos: lack of a correlation between transformation and TRE-dependent trans-activation.

Oncogene - 1 Oct 1992

Jooss K, Müller R

Abstract excerpt

We have identified and characterized a mutant v-Fos protein (DN16G) that is temperature sensitive for transformation. This protein contains an asparagine to glycine substitution at position 156 in the basic region encompassing the DNA contact site. This point mutation also strongly decreases tran...

Topics

Cell Transformation, Neoplastic
DNA
Gene Expression
HeLa Cells
Humans
Mutation
Oncogene Proteins v-fos
Proto-Oncogene Proteins c-jun
Temperature
Tetradecanoylphorbol Acetate
Transcriptional Activation

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