Translational readthrough at nonsense mutations in the HSF1 gene of Saccharomyces cerevisiae.

doi:10.1007/BF00538696

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Translational readthrough at nonsense mutations in the HSF1 gene of Saccharomyces cerevisiae.

Molecular & general genetics : MGG - 1 Sept 1992

Kopczynski J B, Raff A C, Bonner J J

Abstract excerpt

The HSF1 gene of Saccharomyces cerevisiae directs the synthesis of the heat shock transcription factor, HSF. The gene is essential; disruption mutations are lethal. Using a plasmid shuffle screen, we isolated mutations in the HSF1 gene after in vitro mutagenesis of plasmid DNA with hydroxylamine. From a collection of both conditional (temperature-sensitive) and unconditional lethal mutations, we recovered...

Topics

Amino Acid Sequence
Codon
Fungal Proteins
Genes, Fungal
Genes, Suppressor
Heat-Shock Proteins
Hot Temperature
Molecular Sequence Data
Mutagenesis
Mutagenesis, Site-Directed
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Point Mutation

Protein Biosynthesis

Restriction Mapping

Saccharomyces cerevisiae

Sequence Alignment

Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 1406583
DOI: 10.1007/BF00538696

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1406583-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Translational readthrough at nonsense mutations in the HSF1 gene of Saccharomyces cerevisiae.PMID 1406583Read ↗

The DNA-binding domain of yeast heat shock transcription factor independently regulates both the N- and C-terminal activation domains.Semantic proximity Read ↗

Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

The DNA-binding domain of yeast Hsf1 regulates both DNA-binding and transcriptional activities.Semantic proximity Read ↗

Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences.Semantic proximity Read ↗

Mutated yeast heat shock transcription factor activates transcription independently of hyperphosphorylation.Semantic proximity Read ↗

Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity.Semantic proximity Read ↗

The cold sensitivity of a mutant of Saccharomyces cerevisiae lacking a mitochondrial heat shock protein 70 is suppressed by loss of mitochondrial DNA.Semantic proximity Read ↗

Knocking down gene function with an RNA aptamer expressed as part of an intron.Semantic proximity Read ↗

De novo appearance and "strain" formation of yeast prion [PSI+] are regulated by the heat-shock transcription factor.Semantic proximity Read ↗

Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo.Semantic proximity Read ↗

Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo.Semantic proximity Read ↗

Mutations in the Schizosaccharomyces pombe heat shock factor that differentially affect responses to heat and cadmium stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.