Article
Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo.
G3 (Bethesda, Md.) - 7 Aug 2013
Moran Ciara, Kinsella Gemma K, Zhang Zai-Rong, Perrett Sarah, Jones Gary W
Abstract excerpt
The yeast Hsp110 chaperone Sse1 is a conserved protein that is a noncanonical member of the Hsp70 protein superfamily. Sse1 influences the cellular response to heat stress and has also been implicated in playing a role in the propagation of prions in yeast. Sse1 can seemingly exert its effects in vivo through direct or indirect actions by influencing the nucleotide exchange activity of canonical cytosolic Hsp70s....
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