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Article

De novo appearance and "strain" formation of yeast prion [PSI+] are regulated by the heat-shock transcription factor.

Genetics - 1 May 2006

Park Kyung-Won, Hahn Ji-Sook, Fan Qing, Thiele Dennis J, Li Liming

Abstract excerpt

Yeast prions are non-Mendelian genetic elements that are conferred by altered and self-propagating protein conformations. Such a protein conformation-based transmission is similar to that of PrP(Sc), the infectious protein responsible for prion diseases. Despite recent progress in understanding the molecular nature and epigenetic transmission of prions, the underlying mechanisms governing prion conformational...

Topics

Alleles
Gene Expression Regulation, Fungal
Heat-Shock Proteins
Polyglutamic Acid
Prions
Protein Structure, Quaternary
Protein Structure, Tertiary
Recombinant Fusion Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Deletion

Transcription Factors

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Identifiers

PMID: 16452152
DOI: 10.1534/genetics.105.054221
PMCID: PMC1461444

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