Article
Characterization and protective properties of attenuated mutants of Salmonella choleraesuis.
Infection and immunity - 1 Nov 1992
Kelly S M, Bosecker B A, Curtiss R
Abstract excerpt
We have constructed crp::Tn10 and cya::Tn10 Salmonella choleraesuis mutants and their fusaric acid-resistant derivatives with deletions (delta) of the Tn10 and adjacent DNA sequences and found them to be avirulent and able to induce protection against a wild-type challenge in 8-week-old BALB/c mice. Mice survived infection with the crp and cya mutants at doses of more than 7 x 10(3) times the oral (p.o.) 50%...
Topics
- Animals
- Bacterial Adhesion
- CHO Cells
- Cell Line
- Cricetinae
- Epithelium
- Genes, Bacterial
- In Vitro Techniques
- Mice
- Mice, Inbred BALB C
- Mutation
- Phenotype