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Article

Protection and immune responses induced by attenuated Salmonella typhimurium UK-1 strains.

Microbial pathogenesis - 1 Mar 1999

Zhang X, Kelly S M, Bollen W, Curtiss R

Abstract excerpt

We previously reported that Salmonella typhimurium SR-11 mutants with deletion mutations in the genes encoding adenylate cyclase (cya) and the cAMP receptor protein (crp) are avirulent and protective in mice. Salmonella typhimurium UK-1 is highly virulent for chicks (oral LD50 of 3x10(3) CFU) and mice (oral LD50 of 8.5x10(3) CFU) and is capable of lethal infections in pigs, calves and horses. We postulated that...

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Identifiers

PMID: 10089152
DOI: 10.1006/mpat.1998.0245

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