Article
Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 1997
Skorupski K, Taylor R K
Abstract excerpt
Insertion mutations in two Vibrio cholerae genes, cya and crp, which encode adenylate cyclase and the cyclic AMP (cAMP) receptor protein (CRP), respectively, derepressed the expression of a chromosomal cholera toxin (CT) promoter-lacZ fusion at the nonpermissive temperature of 37 degrees C. In th...
Topics
- Agglutination
- Animals
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Carrier Proteins
- Cholera Toxin
- Cyclic AMP
- Cyclic AMP Receptor Protein
- DNA-Binding Proteins
- Fimbriae Proteins
- Fimbriae, Bacterial
- Gene Expression Regulation, Bacterial
- Genes, Reporter
- Mice
- Mutation
- Recombinant Fusion Proteins
- Transcription Factors
- Vibrio cholerae